| Pair Name | Angelicin, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | Angelicin (PubChem CID: 10658 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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| Pair Name | Angelicin, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C90.Z] | Renal carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Down-regulation | Expression | CFLAR | hsa8837 | |
| In Vitro Model | Caki-1 | Clear cell renal cell carcinoma | Homo sapiens (Human) | CVCL_0234 |
| Result | This study provides evidence that angelicin might be a TRAIL sensitizer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Angelicin potentiates TRAIL-induced apoptosis in renal carcinoma Caki cells through activation of caspase 3 and down-regulation of c-FLIP expression. Drug Dev Res. 2018 Feb;79(1):3-10. doi: 10.1002/ddr.21414. | Click |
